- Source
- Research Output Journal of Education
- Published
- 4 Apr 2026
- Authors
- Kakembo Aisha Annet
Excerpt from source
Polygenic risk scores (PRS) are emerging tools in genomic medicine that estimate an individual’s genetic susceptibility to complex diseases by aggregating the effects of multiple genetic variants. While PRS hold promise for advancing precision medicine, their application in Indigenous communities raises significant ethical, legal, and social concerns. This paper examines the implications of PRS within Indigenous contexts, focusing on informed consent, governance frameworks, trust-building, and data sovereignty. It highlights the limitations of PRS derived predominantly from European ancestry datasets, which undermine their predictive validity and exacerbate existing health inequities for…
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