- Source
- SSM: Population Health
- Published
- 4 Dec 2025
- Authors
- A. Rolleston, Gregory T. Jones, N. Earle, S. Gibbs, A. Pilbrow, Allamanda F. Faatoese, et al.
Excerpt from source
Epigenetic research, particularly DNA methylation (DNAm), holds significant potential for improving cardiovascular disease (CVD) risk prediction, yet its application must be guided by ethical and culturally responsive considerations. This paper examines the integration of a values-based framework to ensure the culturally safe conduct of DNAm research within the Multi-Ethnic New Zealand Study of Acute Coronary Syndromes (MENZACS) cohort. Grounded in Te Tiriti o Waitangi principles and kaupapa Māori methodologies, this study emphasises equity, social accountability, and indigenous data sovereignty. This study was not designed as a discovery epigenome wide analysis, but rather performed, as an…
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